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Special Seminar - Dr Frances-Rose Schumacher

Genentech, USA

Ubiquitin Signalling in Disease

Biochemistry Seminar Room 231
Mar. 27, 2017
  • 12:00

My research focuses on ubiquitylation-based signalling pathways that impact human disease. I will present work from two distinct projects, one from my time at Genentech and the other from work performed at the MRC PPU at the University of Dundee. I will also briefly overview the Genentech Post Doctoral program.

 Major histocompatibility complex Class I (MHCI) presented peptides play a critical role in generating effective immune responses.   MHCI peptides may be generated via ubiquitylation-driven degradation of proteins into peptide fragments.  Mass spectrometry based methodologies to define MHCI peptides will be outlined along with my ongoing efforts to determine how each stage of MHCI peptide processing influences peptide presentation.

 The Cullin-RING-ligases (CRLs) belong to a large ubiquitin-ligase family that utilize adaptor molecules for specificity and signalling.   The mutation of CRL3 causes a severe form of familial hypertension known as pseudohypoaldosteronism type IIE (PHA2E). I will describe my study elucidating the role of CRL3 in blood pressure signalling pathways.