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PhD Seminar - Roman Mortuza

Biochemistry Department, University of Otago

Phenotypic and Molecular Analysis of the Alanine and Glutamate Racemases of Mycobacteria

Biochemistry Seminar Room 231
May. 02, 2017
  • 12:00

The enzymes alanine racemase (Alr) and glutamate racemase (MurI) catalyze the formation of the essential building blocks, D-alanine and D-glutamate, respectively, for cell wall biosynthesis. Mycobacterial Alr and MurI have been proposed as targets for anti-tuberculosis drug design because of gene deletion experiments that suggested their essentiality. Despite their essential cellular role, very little is known about their regulation in response to various environmental stimuli and conditions where these genes might become non-essential for growth.  The aim of this PhD project was to study the regulation and function of alr and murI genes in Mycobacterium smegmatis