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PhD Seminar - Ben Peters

Investigation Into The Transcriptional Regulation Of DUO1: Determining The Fate Of The Male Germline In Flowering Plants.

Biochemistry Seminar Room 231
Jul. 18, 2017
  • 12:00 — 13:00

The pollen grain is responsible for the production and delivery of sperm cells to the female gametes in flowering plants. During the early stages of pollen development there is an asymmetric division that is critical for the specification of the male germ cell. In this germ cell, shortly after the division, the transcription factor DUO1 is expressed. DUO1 controls the differentiation of the germline through activating a suite of genes required for cell cycle progression and sperm cell function. Thus, the early germ cell specific expression of DUO1 is a key step in the specification of the male germline. I investigated the transcriptional control of DUO1 expression.

I identified key promoter sequences required for the germline-specific regulation of DUO1 transcription. Utilising phylogenetic footprinting in eudicots and in Arabidopsis accessions, I identify a cis-regulatory module, Regulatory region of DUO1 (ROD1), which replicates the expression pattern of DUO1 in Arabidopsis (Arabidopsis thaliana). Further investigation into the function of the cis-elements contained within ROD1 identified potential transcription factor binding sites, and their associated transcription factors, which may be required for the specification of the male germline in flowering plants. 

View paper at the journal's website.