Speaker Calendar » 2017 Schneider
The low-density-lipoprotein receptor (LDLR) is the key player in a complex regulatory pathway for maintaining cholesterol homeostasis. Dysfunctions of the LDLR pathway lead to pathological hypercholesterolemias, the best known of which is Familial Hypercholesterolemia, caused by mutations in the LDLR gene. Recent studies have identified and characterized novel members of the LDLR family termed LDLR relatives (LRs). I will present significant examples for the diversity of these membrane proteins in order to show the broad spectrum of LR functions, and will describe their physiological roles as well as biological consequences of mutations in their genes. We have gained important insights into the involvement of LRs in oocyte growth in oviparous species, transport of lipoproteins across the avian yolk sac, and mechanisms of cell migration in human atherosclerosis.