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Special Seminar - Peter Mace

Otago University

(Pseudo) Kinase Signalling and Beyond

Biochemistry Seminar Room 231
May. 15, 2017
  • 12:00

Post-translational modification of signalling proteins has vast influence on eukaryotic cells, and is frequently disrupted in human disease. In this seminar, I will discuss ongoing research in my laboratory that aims to understand protein signalling mechanisms at the atomic level.

 ‘Tribbles’ pseudokinases (TRIB1–3) cooperate with the COP1 ubiquitin ligase to regulate transcription factors in various cancers. Our recent TRIB1 structures allow us to propose an integrated mechanism of substrate and COP1 recruitment by TRIB1, which could impact efforts to therapeutically target Tribbles proteins. Similarly, characterisation of the apoptosis signal-regulating kinase family (ASK1–3) has offered new insight into their roles in translating cellular stress signals into coherent MAP kinase signalling. Our studies of ASK and Tribbles proteins will be presented in the context of wider efforts to understand errant protein function across a spectrum of human diseases. 

View paper at the journal's website.