Ruth Topless

Assistant Research Fellow
Ruth Topless Merriman Lab
  • Biochemistry Department
  • School of Biomedical Sciences
  • University of Otago
  • P.O. Box 56
  • 710 Cumberland St
  • Dunedin 9054 , New Zealand
  • Tel.: 64 3 479-4167
  • Fax: 64 3 479-7866
  • Email:ruth.topless@otago.ac.nz

Selected Publications

Pedro M Azevedo, Tony R Merriman, Ruth K Topless, Nigel J Wilson, Sue Crengle, and Diana R Lennon., Association study involving polymorphisms in IL-6, IL-1RA, and CTLA4 genes and rheumatic heart disease in New Zealand population of Māori and Pacific ancestry., Cytokine 2016 vol. 85 pp. 201-206., Link »

Sarah E Morton, Kirstie J M O'Hare, Jaimee L K Maha, Max P Nicolson, Liana Machado, Ruth Topless, Tony R Merriman, and Richard J Linscott., Testing the Validity of Taxonic Schizotypy Using Genetic and Environmental Risk Variables., Schizophr Bull 2016 p. sbw108., Link »

Humaira Rasheed, Amanda J Phipps-Green, Ruth Topless, Malcolm D Smith, Catherine Hill, Susan Lester, Maureen Rischmueller, Matthijs Janssen, Timothy L Jansen, Leo A Joosten, Timothy R Radstake, Philip L Riches, Anne-Kathrin Tausche, Frédéric Lioté, Alexander So, Andre van Rij, Gregory T Jones, Sally P McCormick, Andrew A Harrison, Lisa K Stamp, Nicola Dalbeth, and Tony R Merriman., Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout., Rheumatology (Oxford) 2016 p. kew057., Link »

R L Roberts, M C Wallace, A J Phipps-Green, R Topless, J M Drake, P Tan, N Dalbeth, T R Merriman, and L K Stamp., ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout., Pharmacogenomics J 2016., Link »

Humaira Rasheed, Cushla Mckinney, Lisa K Stamp, Nicola Dalbeth, Ruth K Topless, Richard Day, Diluk Kannangara, Kenneth Williams, Malcolm Smith, Matthijs Janssen, Tim L Jansen, Leo A Joosten, Timothy R Radstake, Philip L Riches, Anne-Kathrin Tausche, Frédéric Lioté, Leo Lu, Eli A Stahl, Hyon K Choi, Alexander So, and Tony R Merriman., The Toll-Like Receptor 4 (TLR4) Variant rs2149356 and Risk of Gout in European and Polynesian Sample Sets., PLoS ONE 2016 vol. 11 (1) p. e0147939., Link »

Cushla Mckinney, Lisa K Stamp, Nicola Dalbeth, Ruth K Topless, Richard O Day, Diluk Rw Kannangara, Kenneth M Williams, Matthijs Janssen, Timothy L Jansen, Leo A Joosten, Timothy R Radstake, Philip L Riches, Anne-Kathrin Tausche, Frédéric Lioté, Alexander So, and Tony R Merriman., Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout., Arthritis Res Ther 2015 vol. 17 (1) p. 288., Link »

R K Topless, T J Flynn, M Cadzow, L K Stamp, N Dalbeth, M A Black, and T R Merriman., Association of SLC2A9 genotype with phenotypic variability of serum urate in pre-menopausal women., Front Genet 2015 vol. 6 (OCT)., Link »

Tahzeeb Fatima, Sara Altaf, Amanda Phipps-Green, Ruth Topless, Tanya J Flynn, Lisa K Stamp, Nicola Dalbeth, and Tony R Merriman., Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout., Rheumatology International 2015, Link »

Tanya J Flynn, Murray Cadzow, Nicola Dalbeth, Peter B Jones, Lisa K Stamp, Jennie Harré Hindmarsh, Alwyn S Todd, Robert J Walker, Ruth Topless, and Tony R Merriman., Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares., BMC Musculoskelet Disord 2015 vol. 16 (1) p. 196., Link »

Nicola Dalbeth, Ruth Topless, Tanya Flynn, Murray Cadzow, Mark J Bolland, and Tony R Merriman., Mendelian randomization analysis to examine for a causal effect of urate on bone mineral density., J Bone Miner Res 2015 vol. 30 (6) pp. 985-991., Link »

A J Phipps-Green, M E Merriman, R Topless, S Altaf, G W Montgomery, C Franklin, G T Jones, A M van Rij, D White, L K Stamp, N Dalbeth, and T R Merriman, Twenty-eight loci that influence serum urate levels: analysis of association with gout., Annals of the Rheumatic Diseases 2014, Link »

Tanya J Flynn, Amanda Phipps-Green, Jade E Hollis-Moffatt, Marilyn E Merriman, Ruth Topless, Grant Montgomery, Brett Chapman, Lisa K Stamp, Nicola Dalbeth, Tony R Merriman, Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects, Arthritis research & therapy Volume 15, Issue 6, Page R220, Link »

H Rasheed, A Phipps-Green, R Topless, J E Hollis-Moffatt, J H Hindmarsh, C Franklin, N Dalbeth, P B Jones, D H N White, L K Stamp, and T R Merriman, Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption, Arthritis Research and Therapy Volume 15, Issue 6, Link »

G T Jones, M J Bown, S Gretarsdottir, S P R Romaine, A Helgadottir, G Yu, G Tromp, P E Norman, C Jin, A F Baas, J D Blankensteijn, I J Kullo, L Victoria Phillips, M J A Williams, R Topless, T R Merriman, T M Vasudevan, D R Lewis, R D Blair, A A Hill, R D Sayers, J T Powell, P Deloukas, G Thorleifsson, S E Matthiasson, U Thorsteinsdottir, J Golledge, R A Ariëns, A Johnson, S Sohrabi, D Julian Scott, D J Carey, R Erdman, J R Elmore, H Kuivaniemi, N J Samani, K Stefansson, and A M van Rij, A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm, Human Molecular Genetics 2013 vol. 22 (14) pp. 2941-2947, Link »

R Debono, R Topless, D Markie, M A Black, and T R Merriman, Analysis of the DISC1 translocation partner (11q14.3) in genetic risk of schizophrenia, Genes, Brain and Behavior 2012 vol. 11 (7) pp. 859-863, Link »

M Chen-Xu, R Topless, C Mckinney, M E Merriman, A Phipps-Green, N Dalbeth, P J Gow, A A Harrison, J Highton, P B Jones, M Nissen, M D Smith, A Van Rij, G T Jones, L Rodriguez-Rodriguez, B Fernandez-Gutierrez, M Teruel, A Balsa, D Pascual-Salcedo, A M Ortiz, M A Gonzalez-Gay, S Steer, M Maehlen, B Lie, B P Wordsworth, L K Stamp, J Martín, and T R Merriman, Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets, Annals of the Rheumatic Diseases 2012 vol. 71 (1) pp. 155-157, Link »