Professor Sally McCormick

Sally McCormick
  • Biochemistry Department
  • School of Biomedical Sciences
  • University of Otago
  • P.O. Box 56
  • 710 Cumberland St
  • Dunedin 9054 , New Zealand
  • Tel.: 64 3 479-7840
  • Fax: 64 3 479-7866
  • Email:sally.mccormick@otago.ac.nz

Research Interests:

Lipoprotein(a)

My laboratory studies the genetics, proteomics and biochemistry of molecules involved in heart disease. A major class of molecule involved in heart disease are the plasma lipoproteins. We have a broad research programme that involves the purification, measurement and quantitative proteomics of plasma lipoproteins from clinical samples as well as the investigation of novel compounds that alter lipoprotein levels using mouse models.   We also investigate the genetics of plasma lipoproteins in families with various dyslipidaemias.

 

 

PhD projects available in this laboratory

Awards

  • Monika Sharma
  • 2016, European Atherosclerosis Society Best Young Investigator Presentation
  • Innsbruck, Austria.
  • Monika Sharma
  • 2016, Best Young Investigator Presentation
  • European Atherosclerosis Society Lp(a) satellite meeting, Innsbruck, Austria.
  • Monika Sharma
  • 2014, Otago Medical School Research Society's Student Science Writing Prize, Runner up
  • For her entry "Lipoprotein(a): step-child in the lipid family"
  • Sally McCormick
  • 2014, OSMS Distinguished Academic Teaching Staff Award

Selected Publications

Monika Sharma, Gregory M Redpath, Michael J Williams, and Sally P McCormick., Recycling of Apolipoprotein(a) After PlgRKT-Mediated Endocytosis of Lipoprotein(a)., Circulation research 2016 p. CIRCRESAHA.116.310272., Link »

M Sharma, G Redpath, and S McCormick., Calcium Dependent Endocytosis and Recycling of Lipoprotein(a) in Hepg2 Cells., Atherosclerosis 2016 vol. 252 pp. E244-E244., Link »

Humaira Rasheed, Amanda J Phipps-Green, Ruth Topless, Malcolm D Smith, Catherine Hill, Susan Lester, Maureen Rischmueller, Matthijs Janssen, Timothy L Jansen, Leo A Joosten, Timothy R Radstake, Philip L Riches, Anne-Kathrin Tausche, Frédéric Lioté, Alexander So, Andre van Rij, Gregory T Jones, Sally P McCormick, Andrew A Harrison, Lisa K Stamp, Nicola Dalbeth, and Tony R Merriman., Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout., Rheumatology (Oxford) 2016 p. kew057., Link »

Erin L Damsteegt, Yuichi Ozaki, Sally P A McCormick, and P Mark Lokman., Triacylglyceride physiology in the short-finned eel, Anguilla australis-the effects of androgen., Am J Physiol Regul Integr Comp Physiol 2016 vol. 310 (5) pp. R422-31., Link »

Monika Sharma, Jo Tuaine, Blair McLaren, Debra L Waters, Katherine Black, Lynnette M Jones, and Sally P A McCormick., Chemotherapy Agents Alter Plasma Lipids in Breast Cancer Patients and Show Differential Effects on Lipid Metabolism Genes in Liver Cells., PLoS ONE 2016 vol. 11 (1) p. e0148049., Link »

Esther M Ooi, Gerald F Watts, Dick C Chan, Jing Pang, Vijay S Tenneti, Sandra J Hamilton, Sally P McCormick, Santica M Marcovina, and P Hugh R Barrett., Effects of Extended-Release Niacin on the Postprandial Metabolism of Lp(a) and ApoB-100-Containing Lipoproteins in Statin-Treated Men With Type 2 Diabetes Mellitus., Arterioscl Throm Vas 2015 p. ATVBAHA.115.306136., Link »

Erin L Damsteegt, Ali Falahatimarvast, Sally P A McCormick, and P Mark Lokman., Triacylglyceride physiology in the short-finned eel, Anguilla australis-changes throughout early oogenesis., Am J Physiol Regul Integr Comp Physiol 2015 vol. 308 (11) pp. R935-44., Link »

Monika Sharma, Anne Von Zychlinski-Kleffmann, Carolyn M Porteous, Gregory T Jones, Michael J A Williams, and Sally P A McCormick., Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids., J Lipid Res 2015 vol. 56 (7) pp. 1318-1328., Link »

Kader, T., Porteous, C. M., Williams, M. J. A., Gieseg, S. P., & McCormick, S. P. A. , Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice., Atherosclerosis (2014) 237(2), 725–733., Link »

Anne von Zychlinski, Michael Williams, Sally McCormick, and Torsten Kleffmann, Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins., Journal of proteomics 2014, Link »

Brie Sorrenson, Rachel J Suetani, Michael J A Williams, Vivienne M Bickley, Peter M George, Gregory T Jones, and Sally P A McCormick, Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate, Journal of lipid research 2013 vol. 54 (1) pp. 55-62, Link »

I. Kardys, R.M. Oemrawsingh, I.P. Kay, G T Jones, S.P. McCormick, J. Daemen, R.J. Van Geuns, E. Boersma, R.T. Van Domburg, and P.W. Serruys, Lipoprotein(a), Interleukin-10, C-Reactive Protein, and 8-Year Outcome After Percutaneous Coronary Intervention, Clinical Cardiology Volume 35, Issue 8, pages 482–489, August 2012, Link »

Euan J Rodger, Rachel J Suetani, Gregory T Jones, Torsten Kleffmann, Alan Carne, Michael Legge, and Sally P A McCormick, Proteomic analysis of aortae from human lipoprotein(a) transgenic mice shows an early metabolic response independent of atherosclerosis., PLoS ONE 2012 vol. 7 (1) p. e30383, Link »

von Zychlinski A, Kleffmann T, Williams MJA and McCormick SPA. (2011) Proteomics of Lipoprotein(a) Identifies a Protein Complement Associated with Response to Wounding. J.Proteomics. 74:2881-2891.

Suetani RJ, Sorrenson B, Tyndall JDA, Williams, MJA and McCormick SPA. (2011) Homology modeling and functional testing of an ABCA1 mutation causing Tangier Disease. Atherosclerosis. 218:404-410.

Roberts RL, Van Rij AM, Phillips LV, Young S, McCormick SPA, Merriman TR, Jones GT. (2011) Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aneurysms.Atherosclerosis.  218:123-126.

Dickerhof N,  Kleffmann T,  Jack, R, and McCormick, SPA. (2011) Bacitracin inhibits the reductive activity of protein disulfide isomerase by forming a disulfide bond with free cysteines in the substrate binding domain.  FEBS J. 278:2034-2043

Sorrenson B, Suetani RJ, Bickley VM, George PM, Williams MJ, Scott RS, McCormick SPA. (2011) An ABCA1 truncation shows no dominant negative effect in a familial hypobetalipoproteinemia pedigree with three ABCA1 mutations.  Biochem. Biophys. Res. Comm. 409:400-5

Rachel J. Brace, Brie Sorrenson, Dmitri Sviridov and Sally P. A. McCormick. (2010)
A gel-based method for purification of apolipoprotein A-I from small volumes of plasma. J. Lipid. Res. 51: 3370-3376

Pedersen, TX, McCormick, SPA, Tsimikas, S, Bro, S and Nielsen, LB. (2010)
Lipoprotein(a) binds oxidized phospholipids and accelerates atherosclerosis in uremic mice. J. Lipid. Res. 51:2967-2975.

Jones GT, Deng M,,Hammond-Tooke GD, McCormick SPA, van Rij AM (2009). Increased plasma Lp(a) found in large artery atherosclerotic, but not small artery occlusive, stroke.  Clin. Chem. 55:1888-1890

Wang, YT, von Zychlinski, A and McCormick SPA. (2009) Dimyristoylphosphotidycholine induces conformational changes in apoB that lowers lipoprotein(a). J. Lipid. Res. In Press

Murphy, AJ, Woollard KJ, Hoang, A, Mukhamedova, N, Stirzaker, RA, McCormick, SPA, Remaley, AT, Sviridov, D, and Chin-Dusting, J. (2008) High-density lipoprotein reduces the human monocyte inflammatory response. Atherio. Thromb. Vasc. Biol. 28:2071-2077.

Slatter, TL, Jones, GT, Williams, MJA, van Rij, AM and McCormick SPA. (2008) Novel rare mutations and promoter haplotypes in ABCA1 contribute to low HDL cholesterol levels. Clin. Genet.73: 179-184

Jones, GT, van Rij, AM, Cole, J, Williams, MJA, Bateman EH, Marcovina, SM, Deng, M and McCormick SPA. (2007) Plasma Lipoprotein(a) Level Indicates Risk for Four Distinct Forms of Vascular Disease. Clin. Chem. 53:679-685.

Slatter, TA, Williams, MJ, Frikke-Schmidt, R, Tybjærg-Hansen, A, Morison, I and McCormick SPA. (2006) Promoter haplotype modulates phenotypic expression of familial hypoalphalipoproteinemia in a novel case of Tangier disease. Atherosclerosis. 187:393-400.

Jones GT, Jiang F, McCormick SPA, Dusting GJ. (2005) Elastic lamina defects are an early feature of aortic lesions in the apolipoprotein E knockout mouse. Journal of Vascular Research. 42:237-246

Sharp, R.J., Perugini, M., Marcovina, S.M., and McCormick, S.P.A. (2004). Structural features of an apolipoprotein B synthetic peptide that inhibits lipoprotein(a) assembly. J. Lipid. Res.45:2227-2234.

Liu, C. Y. Y., Broadhurst, R., Marcovina, S. M., and McCormick, S. P. A. (2004). Mutation of lysine residues in apolipoprotein B100 causes defective lipoprotein(a) formation. J. Lipid Res.45:63-70.

Sharp, R.J., Perugini, M., Marcovina, S.M., and McCormick, S.P.A. (2003). A synthetic peptide that inhibits lipoprotein(a) assembly. Arterio.Thromb. Vasc. Biol. 23:502-507.

McCormick, S. P. A., Liu, C. Y-Y., Young, S. G., & Nielsen, L. B. (2003). Manipulating large insert clones for transgenesis. In M. H. Hofker & J. van Deursen (Eds.), Methods in molecular biology: Transgenic mouse methods and protocols (pp. 105-123). Totowa, NJ: Humana Press.