Pox viruses and herpes viruses have evolved numerous strategies to evade the host immune system and ensure their own survival. They often viruses encode secreted chemokine binding proteins (CKBPs) that modulate inflammation by interfering with host chemokine signaling.
We are studying the molecular interactions between viral CKBPs and host chemokines in order to gain new insight into CKBP-chemokine binding and thus viral modulation of host chemokine signaling. This work involves structural (eg. x-ray crystallography), biophysical (eg. surface plasmon resonance) as well as sequence-based analysis.