Professor Kurt Krause

Head of Department, Director of the Webster Centre for Infectious Diseases
KurtKrause
  • Biochemistry Department
  • School of Medical Sciences
  • University of Otago
  • P.O. Box 56
  • 710 Cumberland St
  • Dunedin 9054 , New Zealand
  • Tel.: 64 3 479-5166, +64 3 479-7864 (HOD office)
  • Fax: 64 3 479-7866
  • Email:kurt.krause@otago.ac.nz
Krause Lab Website

Research Interests:

Structural biology of infectious diseases, structure-aided drug design, protein crystallography, x-ray diffraction, structure and function of enzymes and proteins including antibiotic targets, redox proteins, nucleases, luciferase, and bacterial pathogenesis factors.

The Webster Centre for Infectious Diseases

Awards

  • Ashley Campbell
  • 2014, Otago School of Medical Sciences Postgraduate Symposium Poster prize, 1st place
  • Ashley Campbell
  • 2014, NZ Structural Biology Meeting Poster Prize

Selected Publications

Yang Li, Roman Mortuza, Daniel L Milligan, Sieu L Tran, Ulrich Strych, Gregory M Cook, and Kurt L Krause, Investigation on the essentiality of Glutamate Racemase in Mycobacterium smegmatis., Journal of Bacteriology 2014, Link »

Emily Davis, Emma Scaletti-Hutchinson, Helen Opel-Reading, Yoshio Nakatani, and Kurt L Krause, The structure of alanine racemase from Acinetobacter baumannii., Acta crystallographica Section F, Structural biology communications 2014 vol. 70 (Pt 9) pp. 1199-1205, Link »

Sharpe ML, Hastings JW, Krause KL, Luciferases and light-emitting accessory proteins: structural biology, eLS John Wiley & Sons, Ltd. (2014), Link »

Estelle S Baker, Sylvia R. Luckner, Kurt L Krause, Paul R Lambden, Ian N Clarke, and Vernon K. Ward, Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein., PLoS ONE 2012 vol. 7 (2) p. e30534, Link »

Emma R. Scaletti, Sylvia R. Luckner, and Kurt L Krause, Structural features and kinetic characterization of alanine racemase from Staphylococcus aureus (Mu50), Acta Crystallographica Section D Biological Crystallography 2012 vol. 68 pp. 82-92, Link »

Im H, Sharpe ML, Strych U, Davlieva M, Krause KL, The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design, BMC Microbiology (2011) 11:116, Link »

K G Anthony, U Strych, K R Yeung, C S Shoen, O Perez, K L Krause, M H Cynamon, P A Aristoff, and R A Koski, New classes of alanine racemase inhibitors identified by high-throughput screening show antimicrobial activity against Mycobacterium tuberculosis, PLoS ONE 2011 vol. 6 (5), Link »

Rafael M Couñago, Milya Davlieva, Ulrich Strych, Ryan E Hill, and Kurt L Krause (2009) Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames), BMC Structural Biology 2009, 9(53) (20 August 2009)

Chuanying Chen, Kurt Krause, B Pettitt . (2008) Advantage of Being a Dimer for Serratia marcescens Endonuclease, J. Physical Chemistry B, 2009, 113(2), 511-521. (Cover Art)

Daniel L. Milligan, Sieu L. Tran, Ulrich Strych, Gregory M. Cook, and Kurt L. Krause, “The Alanine Racemase of Mycobacterium smegmatis is Essential for Growth in the Absence of D-Alanine” J. Bacteriol. 189 (22) 8381-8386. (Published ahead of print on 7 September 2007, doi:10.1128/JB.01201-07)

Ulrich Strych, Milya Davlieva, Joseph P. Longtin, Eileen L. Murphy, Hookang Im, Michael J. Benedik, and Kurt L. Krause, “Purification and preliminary crystallization of alanine racemase from Streptococcus pneumoniae ” (2007) BMC Microbiology, 7:40 (17 May 2007).

Weksberg, T. E., Lynch, G. C., , Krause, K. L., Pettitt, B. M. “Molecular Dynamics Simulations of Trichomonas vaginalis Ferredoxin Show Loop-Cap Transition” (2007) Biophysical J., 92: 3337-3345.

Chen, C. I., Beck, B.W., Krause, K., Weksberg, T. E., Pettitt, B. M. “Effects of dimerization of Serratia marcescens endonuclease on water dynamics” (2007) Biopolymers, 85 (3): 241-252.

Hastings, J.W. and Krause, K. L., “Luciferases and Light Emitting Accessory Proteins: Structural Biology” (2006) Nature Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichesterhttp://www.els.net/ [doi:10.1038/npg.els.0003064].

Chen, C. I., Beck, B.W., Krause, K. Pettitt, B. M. “Solvent Participation in Serratia marcescens Endonuclease Complexes” (2005) Proteins: Structure, Function and Bioinformatics, 62 (4): 982-99.

Shelburne, S. A., 3rd, Visnegarwala, F., Adams, C., Krause, K. L., Hamill, R. J., and White, A. C., Jr. (2005) Unusual manifestations of disseminated Histoplasmosis in patients responding to antiretroviral therapy, Am J Med 118, 1038-1041.

LeMagueres, P, Im, H, Ebalunode, J, Strych, U, Benedik, MJ, Briggs, JM, Kohn, H and Krause,KL “The 1.9 Å crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site”, (2005) published online, http://dx.doi.org/10.1021/bi0486583.

LeMagueres P, Im H, Dvorak A, Strych U, Benedik M, Briggs J, Krause KL. Crystal structure at 1.45 Å resolution of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms. Biochemistry. 2003;42(50):14752-61.

Kim MG, Ulrich S, Krause KL, Benedik M, Kohn H. Evaluation of Amino-substituted Heterocyclic Derivatives as Alanine Racemase Inhibitors. Medicinal Chemistry Research. 2003;12(3) 130-138.

Krause KL. Nanotech 2003 - Nanotechnology Conference and Trade Show. Structure-aided drug design. Idrugs. 2003;6(4):309-311.

Kim MG, Strych U, Krause KL, Benedik MJ, Kohn H. N(2)-substituted D,L-cycloserine derivatives: synthesis and evaluation as alanine racemase inhibitors. The Journal of Antibiotics. 2003;56, 160-168.

Liu L, Im H, Cegielski M, LeMagueres P, Schultz LW, Krause KL, Hastings JW. Characterization and Crystallization of Active Domains of a Novel Luciferase from a Marine Dinoflagellate. Acta Crystalogr D Biol Crystallogr. 2003;59, 2003, 761-764.

Vidakovic M, Crossnoe C, Neidre C, Kim K, Krause KL, Germanas JP. Reactivity of reduced [2Fe-2S] ferredoxins parallels host susceptibility towards nitroimidazoles. Antimicrob Agents and Chemother 2003;47(1): 302–308.

Krause, Kurt L. and Miller, Mitchell D., A new engine for cleaving nucleic acid, In Structures and Mechanisms: From Ashes to Enzymes, Gareth R. Eaton, Don C. Wiley, and Oleg Jardetzky, eds., ACS Symposium Series Volume 827, Oxford University Press, 2002 pp. 270-293.

Crossnoe, C. R., Germanas, J. P., LeMagueres, P., Mustata, G. and K. L. Krause, The Crystal Structure of Trichomonas vaginalis Ferredoxin Provides Insight into Metronidazole Activation, (2002) J. Mol. Biol. (2002) 318:503-518.

Bussiere, D. and K. Krause, Biotechnology and Drug Discovery: Two years into the new millennium, In Technical Proceedings of the Second International Conference on Computational Nanoscience and Nanotechnology, Matthew Laudon and Bart Romanowicz, eds. Computational Publications, Cambridge. MA. (2002) pp. 44-49.

Musher, D. M., Dowell, M.E., Shortridge, V.D., Flamm, R.K., Jorgensen, J.H., Magueres, P. and K. L. Krause, Emergence of macrolide resistance during treatment of pneumococcal pneumonia with azithromycin. (2002) New England J. Med., 346: 630-631.

Strych, U., Penland, R. L., Jimenez, M., Krause, K.L. and M.J. Benedik, Characterization of the alanine racemases from two Mycobacteria (2001) FEMS Microbiology Letters, 196: 93-98.

Krause, K. L. and Miller, M. D., Using Electrostatics to Define the Active Site of Serratia Endonuclease In Methods in Molecular Biology: Nuclease Methods and Protocols. Eds. C. Schein, Humana Press, Totowa, NJ (2001), 160: 249-261.

U. Strych, H. Huang, K. Krause, and M. Benedik, Characterization of the Alanine Racemases from Pseudomonas aeruginosa PAO1, (2000) Current Microbiology, 41: 290-294.