We have previously identified the first naturally occurring mutation in cytochrome c, associated with inherited thrombocytopenia (Morison et al, Nature Genetics (2008)). We are now investigating the molecular mechanisms underlying other novel cases of inherited thrombocytopenia. The aim of this work is to identify new proteins and pathways involved in platelet formation in humans. This project will involve a combination of functional analyses of identified proteins, and characterisation of platelet formation using hematopoietic stem cells and modified cell lines. Students with a strong background in cell biology and an interest in protein biochemistry and molecular mechanisms of disease are sought to join our research group.