Metabolism provides the fuels and molecules for life. How metabolic processes are regulated and coordinated in animals. Human disease states that arise from metabolic imbalances.
This course emphasises the regulation of metabolism and the integration of metabolic processes in animals. We look at the way that carbon and nitrogen are fixed and utilized by plants and animals, how human metabolism is affected by normal physiological events, such as fasting and exercise, and how signalling occurs in human metabolism. We also look at changes that can occur as a result of disease.
Introduction to Human Metabolism and its Regulation (1 lecture)
Introduction and video A Question of Fuel Supply
Utilisation of fuels (4 lectures)
Fundamental energy production and synthesis of energy stores
Analysis of data (1 lecture)
Collection and analysis of data, distributions and statistical manipulations of data, methods of presenting and displaying results, interpretation and limitations of results
Metabolism of fed and fasting states in animals (5 lectures)
Regulation, by both hormones and diet, of glycogen synthesis, gluconeogenesis, fat synthesis and storage, lipolysis and ketogenesis.
Regulation of human metabolism (5 lectures)
The regulation and integration of human metabolism as illustrated by lipoprotein disorders, metabolic syndrome, diabetes, and trauma. The role of hormones; insulin, glucagon, cortisol, adrenaline, and eicosanoids
Nitrogen metabolism: how organisms acquire, use, and dispose of nitrogen (4 lectures)
Nitrogen fixation, aminotransferases, amino acid catabolism, excretion and nitrogen balance, transport of nitrogen between tissues in animals
Production of core metabolic molecules in plants (5 lectures)
Assimilation and utilisation of carbon in plants; production of NADPH and utilisation in lipid metabolism, carbon fixation, carbon assimilation pathways triose and sucrose, storage and mobilisation of carbohydrates starch and cellulose; cellulose metabolism in ruminants and micro-organisms
Molecular components of cellular signalling (5 lectures)
Receptors, second messengers, kinases and phosphatases