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F Perez-Ruiz, M A Aniel-Quiroga, A M Herrero-Beites, S P Chinchilla, G G Erauskin, and T Merriman., Rheumatology International, 13 March 2015, 6p
Gout is caused by high levels of uric acid which precipitate in the joints and can trigger a very painful immune reaction. Very important in the control of uric acid levels is the ability of the kidney to excrete uric acid in the urine. This paper investigated factors important in this process, in a clinically very well defined patient group from Spain. By measuring in the blood and urine various biochemical markers such as glucose, sodium and insulin this paper showed that factors that increase the chance of diabetes and high blood pressure (insulin resistance and lower secretion of sodium) lead to reduced excretion of uric acid and increased risk of gout