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Monika Sharma, Anne Von Zychlinski-Kleffmann, Carolyn M Porteous, Gregory T Jones, Michael J A Williams, and Sally P A McCormick., J Lipid Res, 2015 vol. 56 (7) pp. 1318-1328.
Lipoprotein(a) [Lp(a)] and high density lipoproteins (HDL ) are cholesterol carrying molecules in the blood. High levels of Lp(a) increase the risk of developing heart disease while high levels of HDL are protective. Interestingly, high levels of Lp(a) and HDL levels are often found together, suggesting a connection between the two. Here we show that the uptake of Lp(a) lipids by liver cells promotes the production of HDL by stimulating the activity of a cholesterol transporter required to make HDL. In conclusion, we have uncovered a novel connection between Lp(a) and HDL which was previously unknown.